Repurposed Drug Database


Adenosine

Original Indication
Conversion to sinus rhythm of paroxysmal supraventricular tachycardia, including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome).
New Indication
For use in conjunction with BCNU in the treatment of brain tumors.

Albuterol

Original Indication
For the prevention and relief of bronchospasm in patients with reversible obstructive airway disease, and for the prevention of exercise-induced bronchospasm.
New Indication
Prevention of paralysis due to spinal cord injury.

Alefacept

Original Indication
Treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy.
New Indication
For use as prophylaxis of rejection in patients receiving allogenic solid organ transplants.

Alendronate

Original Indication
Treatment and prevention of osteoporosis in postmenopausal women; Treatment to increase bone mass in men with osteoporosis. Treatment of glucocorticoid-induced osteoporosis in men and women receiving glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who have low bone mineral density;Treatment of Paget s disease of bone in men and women.
New Indication
Treatment of osteogenesis imperfecta in pediatric patients 4 years of age and older.

Alfentanil

Original Indication
Alfentanil Injection is indicated: as an analgesic adjunct given in incremental doses in the maintenance of anesthesia with barbiturate/nitrous oxide/oxygen; as an analgesic administered by continuous infusion with nitrous oxide/oxygen in the maintenance of general anesthesia; as a primary anesthetic agent for the induction of anesthesia in patients undergoing general surgery in which endotracheal intubation and mechanical ventilation are required; as the analgesic component for monitored anesthesia care.
New Indication
Treatment of painful HIV-associated neuropathy.

Alprostadil

Original Indication
Treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
New Indication
Treatment of severe peripheral arterial occlusive disease (critical limb ischemia) in patients where other procedures, grafts or angioplasty, are not indicated.

Alteplase

Original Indication
Restoration of funciton to central venous access devices as assessed by the ability to withdraw blood.
New Indication
Treatment of intraventricular hemmorage associated with intracerebral hemmorrhage.

Amiloride HCl solution for inhalation

Original Indication
As adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension to: help restore normal serum potassium levels in patients who develop hypokalemia on the kaliuretic diuretic; prevent development of hypokalemia in patients who would be exposed to particular risk if hypokalemia were to develop, e.g, digitalized patients or patients with significant cardiac arrhythmias.
New Indication
Treatment of cystic fibrosis.

Aminocaproic acid

Original Indication
Useful in enhancing hemostasis when fibrinolysis contributes to bleeding.
New Indication
For the topical treatment of traumatic hyphema of the eye.

Aminolevulinic acid hydrochloride

Original Indication
The LEVULAN KERASTICK for Topical Solution, a porphyrin precursor, plus blue light illumination using the BLU-U Blue Light Photodynamic Therapy Illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
New Indication
Treatment of esophageal dysplasia.

Apomorphine

Original Indication
For the acute, intermittent treatment of hypomobility, off episodes ( end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson s disease.
New Indication
For the treatment of patients in a vegetative state or minimally conscious state for up to 12 months following a severe traumatic brain injury (traumatic or spontaneous).

Arcitumomab

Original Indication
Useful for the detection of presence, location, and extent of recurrent and metastatic colorectal adenocarcinoma involving the liver, extrahepatic abdomen, and pelvis.
New Indication
Diagnosis and localization of primary, residual, recurrent and metastatic medullary thyroid carcinoma.

Aripiprazole

Original Indication
A. as oral formulations for the: 1.Treatment of schizophrenia (Adults & Adolescents [ages 13-17]); 2. Acute treatment of manic or mixed episodes associated with bipolar I disorder as monotherapy and as an adjunct to lithium or valproate (Adults & Pediatric Patients [ages 10-17]), Maintenance treatment of bipolar I disorder (Adults); 3. Adjunctive treatment of major depressive disorder (Adults); 4.Treatment of irritability associated with autistic disorder (Pediatric Patients [ages 6-17 years]). B. as an injection for the: Acute treatment of agitation associated with schizophrenia or bipolar I disorder (Adults).
New Indication
Treatment of Tourette's syndrome.

Ascorbic acid

Original Indication
A vitamin. An ingredient of approved multi-vitamins.
New Indication
Treatment of scurvy.

Atomoxetine hydrochloride

Original Indication
Treatment of Attention Deficit Hyperactivity Disorder.
New Indication
Treatment of Tourette's Syndrome.

Alglucerase injection

Original Indication
Use as a long-term enzyme replacement therapy for children, adolescents and adult patients with a confirmed diagnosis of Type I Gaucher disease who exhibit signs and symptoms that are severe enough to result in one or more of the following conditions: a. moderate-to-severe anemia; b. thrombocytopenia with bleeding tendency; c. bone disease; d.significant hepatomegaly or splenomegaly.
New Indication
Replacement therapy in patients with Type II and III Gaucher's disease.

Alitretinoin

Original Indication
Topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
New Indication
Treatment of acute promyelocytic leukemia.

Alpha1-Proteinase Inhibitor (Human)

Original Indication
For chronic replacement therapy of individuals having congenital deficiency of alpha1- proteinase inhibitor with clinically demonstrable panacinar emphysema.
New Indication
Treatment of cystic fibrosis.

Ambrisentan

Original Indication
Treatment of pulmonary arterial hypertension (WHO group I) in patients with WHO class II or III symptoms to improve exercise capacity and delay clinical worsening.
New Indication
Treatment of idiopathic pulmonary fibrosis.

Amifostine

Original Indication
To reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer.
New Indication
For use as a chemoprotective agent for cyclophosphamide in the treatment of advanced ovarian carcinoma.

Anagrelide

Original Indication
Treatment of patients with essential thrombocythemia to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms.
New Indication
Treatment of polycythemia vera.

Anti-tac (human)

Original Indication
Prophylaxis of acute organ rejection in patients receiving renal transplants, to be used as a part of an immunosuppressive regimen that includes cyclosporine and corticosteroids.
New Indication
Prevention of acute graft-vs-host disease following bone marrow transplantation.

Arsenic trioxide

Original Indication
For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy, and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression.
New Indication
Treatment of multiple myeloma.

Atovaquone

Original Indication
For the acute oral treatment of mild to moderate Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole.
New Indication
Treatment and suppression of Toxoplasma gondii encephalitis.

Azacitidine

Original Indication
Treatment of patients with the following myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia and requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia.
New Indication
Treatment of acute myeloid leukemia.

Adalimumab

Original Indication
1. Rheumatoid Arthritis - Reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active disease. 2. Psoriatic Arthritis - Reducing signs and symptoms of active arthritis, inhibiting the progression of structural damage, and improving physical function. 3. Ankylosing Spondylitis - Reducing signs and symptoms in patients with active disease. 4. Crohn s Disease - Reducing signs and symptoms and inducing and maintaining clinical remission in adult patients with moderately to severely active Crohn s disease who have had an inadequate response to conventional therapy. Reducing signs and symptoms and inducing clinical remission in these patients if they have also lost response to or are intolerant to infliximab. 5. Plaque Psoriasis - The treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phot
New Indication
Treatment of pediatric Crohn's disease.

Aldesleukin

Original Indication
Treatment of adults with metastatic melanoma.
New Indication
Treatment of primary immunodeficiency disease associated with T-cell defects.

Allopurinol

Original Indication
Management of patients with leukemia, lymphoma, and solid tumor malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels and who cannot tolerate oral therapy.
New Indication
Treatment of Chagas' disease.

Aminosidine (Paromomycin)

Original Indication
It is indicated for intestinal amebiasis acute and chronic.
New Indication
Treatment of tuberculosis.

Azathioprine

Original Indication
Azathioprine is indicated for the management of active rheumatoid arthritis to reduce signs and symptoms.
New Indication
Treatment of oral manifestations of graft-versus-host disease.

Aztreonam

Original Indication
It is indicated for the treatment of the infections caused by various susceptible gram-negative microorganisms. See http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050580s040,050632s013lbl.pdf.
New Indication
Improvement of respiratory symptoms in patients with bronchiectasis and gram-negative bacteria in the airways.

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