Repurposed Drug Database


Bupropion

Original Indication
Depression.
New Indication
Smoking cessation.

Buprenorphine

Original Indication
pain.
New Indication
Opiate addiction.

Bacitracin

Original Indication
The use of intramuscular bacitracin should be limited to the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug.
New Indication
Treatment of antibiotic-associated pseudomembranous enterocolitis caused by toxins A and B elaborated by Clostridium difficile.

Beclomethasone 17,21-diproprionate

Original Indication
Relief of the symptoms of seasonal or perennial rhinitis in those cases poorly responsive to conventional treatment. It is also indicated for the prevention of recurrence of nasal polyps following surgical removal.
New Indication
For oral administration in the treatment of intestinal graft-versus-host disease.

Bethanidine sulfate

Original Indication
Treatment of hypertension.
New Indication
Treatment of primary ventricular fibrillation.

Bivalirudin

Original Indication
Use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty.
New Indication
For use as an anticoagulant in patients with or at risk of heparin-induced thrombocytopenia/heparin-induced thrombocytopenia thrombosis syndrome.

Brimonidine

Original Indication
Indicated for the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
New Indication
Treatment of anterior ischemic optic neuropathy.

Bupivacaine

Original Indication
Indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.
New Indication
Relief of persistent pain asociated with postherpetic neuralgia.

Beractant (Bovine surfactant extract)

Original Indication
Treatment of ("rescue") of premature infants with Respiratory Distress Syndrome confirmed by x-ray and requiring mechanical ventilation.
New Indication
Treatment of full-term newborn infants with respiratory failure caused by meconium aspiration syndrome, persistent pulmonary hypertension of the newborn, or pneumonia and sepsis.

Bosentan

Original Indication
Treatment of pulmonary arterial hypertension (WHO Group I) in patients with WHO Class II - IV symptoms, to improve exercise ability and decrease the rate of clinical worsening .
New Indication
Treatment of idiopathic pulmonary fibrosis.

Busulfan

Original Indication
Busulfan injection is indicated for use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.
New Indication
Treatment of primary brain malignancies.

Bevacizumab

Original Indication
Glioblastoma, as a single agent for patients with progressive disease following prior therapy.
New Indication
Treatment of ovarian cancer.

Bleomycin sulfate

Original Indication
Bleomycin has been shown to be useful in the management of the following neoplasms either as a single agent or in proven combinations with other approved chemotherapeutic agents: Squamous cell carcinoma from head and neck; Lymphomas (Hodgkin's and non-Hodgkin's); Testicular Carcinoma (embryonal cell, choriocarcinoma and teratocarcinoma).
New Indication
Treatment of pancreatic cancer.

Botulinum toxin type A

Original Indication
BOTOX Cosmetic is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adult patients 65 years of age.
New Indication
Treatment of dynamic muscle contracture in pediatric cerebral palsy patients.

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