Repurposed Drug Database


Chlorpromazine

Original Indication
Anti-emetic/antihistamine.
New Indication
Non-sedating tranquillizer.

Chlorhexidine

Original Indication
oral gingivitis.
New Indication
oral mucositis.

Celecoxib

Original Indication
Osteoarthritis and adult rheumatoid arthritis.
New Indication
Familial adenomatous polyposis.

Calcium carbonate

Original Indication
Antacid.
New Indication
Treatment of hyperphosphatemia in patients with end stage renal disease.

Chlorhexidine gluconate mouthrinse

Original Indication
For use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing.
New Indication
For use in the amelioration of oral mucositis associated with cytoreductive therapy used in conditioning patients for bone marrow transplantation therapy.

Clindamycin

Original Indication
Treatment of serious infections caused by susceptible anaerobic bacteria, as well as streptococci, pneumococci and staphlococci. See details at: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=15339#nlm34067-9.
New Indication
Treatment of Pneumocystis carinii pneumonia associated with AIDS patients.

Clonazepam

Original Indication
1. Seizure Disorders: Useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. It may be useful in patients with absence seizures (petit mal) who have failed to respond to succinimides. 2. Panic Disorder: Treatment of panic disorder, with or without agoraphobia, as defined in DSM-IV.
New Indication
Treatment of hyperekplexia (startle disease).

Calfactant

Original Indication
Treatment and prevention of respiratory failure due to pulmonary surfactant deficiency in preterm infants.
New Indication
Acute respiratory distress syndrome.

Canakinumab

Original Indication
Treatment of cryopyrin-associated periodic syndromes, in adults and children 4 years of age and older including: Familial Cold Autoinflammatory Syndrome and Muckle-Wells Syndrome.
New Indication
Treatment of systemic onset juvenile idiopathic arthritis.

Capsaicin

Original Indication
Management of neuropathic pain associated with postherpetic neuralgia.
New Indication
Treatment of erythromelalgia.

Cladribine

Original Indication
Treatment of hairy cell leukemia.
New Indication
Treatment of chronic lymphocytic leukemia.

Clofarabine

Original Indication
Treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia after at least two prior regimens.
New Indication
Treatment of acute myelogenous leukemia.

Coagulation Factor VIIa (Recombinant)

Original Indication
Treatment of bleeding episodes in hemophilia A or B patients with inhibitors to Factor VIII or Factor IX.
New Indication
Treatment of bleeding episodes in Glanzmann's thrombasthenia.

Cysteamine hydrochloride

Original Indication
Treatment of nephropathic cystinosis in adults and children.
New Indication
Treatment of corneal cystine crystal accumulation in cystinosis patients.

Cytomegalovirus immunoglobulin intravenous (human)

Original Indication
#1) Attenuation of primary CMV disease associated with kidney transplant recipients who are seronegative for CMV and who receive a kidney from a CMV seropositve donor; #2) Prophylaxis of CMV disease associated transplantation of kidney (all other), lung,.
New Indication
For use in conjunction with ganciclovir sodium for the treatment of cytomegalovirus pneumonia in bone marrow transplant patients.

Cetuximab

Original Indication
As a single agent, EGFR-expressing metastatic colorectal cancer after failure of both irinotecan- and oxaliplatin-based regimens or in patients who are intolerant to irinotecan-based regimens.; In combination with irinotecan, EGFR-expressing metastatic colorectal carcinoma in patients who are refractory to irinotecan-based chemotherapy.
New Indication
Treatment of pancreatic cancer.

Collagenase (lyophilized) for injection

Original Indication
Collagenase Santyl Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.
New Indication
Treatment of Peyronie's disease.

Cyclosporine

Original Indication
Prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants. It is always to be used with adrenal corticosteroids. The drug may also be used in the treatment of chronic rejection in patients previously treated with other immunosuppressive agents. .
New Indication
Treatment of acute rejection in patients requiring allogenic lung transplants.

Cyclosporine 2% ophthalmic ointment

Original Indication
Increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with deratoconjunctivites sicca.
New Indication
Treatment of severe keratoconjunctivitis sicca associated with Sjogren's syndrome.

Load More