Repurposed Drug Database


Duloxetine

Original Indication
Depression.
New Indication
Stress urinary incontinence.

Doxycycline

Original Indication
Bacterial infection.
New Indication
Periodontitis.

Dapoxetine

Original Indication
Analgesia and depression.
New Indication
Premature ejaculation.

Dapsone

Original Indication
To control the dermatologic symptoms of Dermatitis herpetiformis. Dapsone is used alone or in combination with other anti-leprosy drugs for leprosy.
New Indication
Prophylaxis of toxoplasmosis in severely immunocompromised patients with CD4 counts below 100.

Difluprednate

Original Indication
Difluprednate ophthalmic emulsion 0.05%, a topical corticosteroid, is indicated for the treatment of inflammation and pain associated with ocular surgery.
New Indication
Treatment of endogenous and traumatic anterior uveitis and panuveitis.

Dexamethasone phosphate

Original Indication
DEXAMETHASONE SODIUM PHOSPHATE solution/ drop is indicated for the treatment of the following conditions: 1. Ophthalmic - Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitides when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation; corneal injury from chemical, radiation, or thermal bums, or penetration of foreign bodies. 2. Otic - Steroid responsive inflammatory conditions of the external auditory meatus, such as allergic otitis externa, selected purulent and nonpurulent infective otitis externa when the hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation.
New Indication
Treatment of corneal graft rejection.

Dextran 1

Original Indication
Dextran 1 is used to prevent severe anaphylactic reactions to infusions of dextran.
New Indication
Treatment of cystic fibrosis.

Dextran 70

Original Indication
Dextran 70 is a plasma volume expander used in the management of hypovolaemic shock.
New Indication
Treatment of recurrent corneal erosion unresponsive to conventional therapy.

Digitoxin

Original Indication
Digitoxin is a cardiac glycoside with positive inotropic activity. It has actions similar to those of digoxin and is used in the management of some cardiac arrhythmias and in heart failure.
New Indication
Treatment of ovarian cancer.

Dimethyl sulfoxide

Original Indication
Symptomatic relief of patients with interstitial cystitis.
New Indication
Treatment of cutaneous manifestations of scleroderma.

Doripenem

Original Indication
Treatment of the following infections caused by designated susceptible bacteria: Complicated intra-abdominal infections; Complicated urinary tract infections, including pyelonephritis. See details at: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=8708#nlm34067-9.
New Indication
Treatment of bronchopulmonary infection in patients with cystic fibrosis who are colonized with Pseudomonas aeruginosa or Burkholderia cepacia.

Daunorubicin liposomal

Original Indication
Daunorubicin hydrochloride in combination with other approved anticancer drugs is indicated for remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
New Indication
Treatment of acute myeloid leukemia.

Decitabine

Original Indication
For treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia.
New Indication
Treatment of chronic myelogenous leukemia.

Doxorubicin

Original Indication
1. Doxorubicin has been used successfully to produce regression in disseminated neoplastic conditions such as breast carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, 2. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.
New Indication
Treatment of hepatocellular carcinoma.

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