Repurposed Drug Database


Ethinyl Estradiol

Original Indication
A synthetic oestrogen with actions similar to those of estradiol. It is frequently used as the oestrogenic component of combined oral contraceptive preparations.
New Indication
Treatment of Turner's syndrome.

Eculizumab

Original Indication
Treatment of paroxysmal nocturnal hemoglobinuria to reduce hemolysis.
New Indication
Treatment of dermatomyositis.

Epoprostenol

Original Indication
Long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
New Indication
Replacement of heparin in patients requiring hemodialysis and who are at increased risk of hemorrhage.

Eflornithine HCl

Original Indication
Treatment of African trypanosomiasis (sleeping sickness), including the West African form (Trypanosoma brucei gambiense).
New Indication
Treatment of Pneumocystis carinii pneumonia in AIDS patients.

Epoetin alpha

Original Indication
Treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitantly administered chemotherapy.
New Indication
Treatment of myelodysplastic syndrome.

Erlotinib Hydrochloride

Original Indication
Treatment of locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen.
New Indication
Treatment of malignant gliomas.

Etanercept

Original Indication
1. Reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active rheumatoid arthritis. 2. Reducing signs and symptoms, inhibiting the progression of structural damage of active arthritis, and improving physical function in patients with psoriatic arthritis. 3. Reducing signs and symptoms in patients with active ankylosing spondylitis. 4. Treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
New Indication
Treatment of Wegener's granulomatosis.

Etidronate disodium

Original Indication
Treatment of hypercalcemia in late-stage cancer patients.
New Indication
Treatment of degenerative metabolic bone disease occurring in patients who require long term (6 months or greater) total parenteral nutrition.

Everolimus

Original Indication
Prophylaxis of organ rejection in adult patients at low-moderate immunologic risk receiving a kidney transplant.
New Indication
Treatment of gastroenteropancreatic neuroendocrine tumors.

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