Repurposed Drug Database


Lapatinib

Original Indication
TYKERB, a kinase inhibitor, is indicated in combination with: (1)capecitabine, for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and trastuzumab. (2)letrozole for the treatment of postmenopausal women with hormone receptor positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is indicated.
New Indication
Treatment of ErbB2 positive gastric cancer.

Leflunomide

Original Indication
Indicated in adults for the treatment of active rheumatoid arthritis:1. to reduce signs and symptoms 2. to inhibit structural damage as evidenced by X-ray erosions and joint space narrowing 3. to improve physical function.
New Indication
Prevention of acute and chronic rejection in patients who have received solid organ transplants.

Levocabastine HCl ophthalmic suspension 005%

Original Indication
Temporary relief of the signs and symptoms of seasonal allergic conjunctivitis.
New Indication
Treatment of vernal keratoconjunctivitis.

Levofloxacin

Original Indication
Treatment of adults ( 18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed in the label.
New Indication
Treatment of pulmonary infections due to Pseudomonas aeruginosa and other bacteria in patients with cystic fibrosis patients.

Lidocaine

Original Indication
Local anaesthesia.
New Indication
Oral corticosteroid-dependent asthma.

L-cysteine

Original Indication
Cysteine Hydrochloride Injection, USP 0.5 gram is indicated for use only after dilution as an additive to Aminosyn (a crystalline amino acid solution) to meet the intravenous amino acid nutritional requirements of infants receiving total parenteral nutrition.
New Indication
For the prevention and lessening of photosensitivity in erythropoietic protoporphyria.

Lenalidomide

Original Indication
For use in combination with dexamethasone for the treatment of multiple myeloma patients who have received at least one prior therapy.
New Indication
Treatment of chronic lymphocytic leukemia.

Levocarnitine

Original Indication
1. Treatment of primary systemic carnitine deficiency. 2. Acute and chronic treatment of patients with an inborn error of metabolism which results in a secondary carnitine deficiency.
New Indication
For the prevention of secondary carnitine deficiency in valproic acid toxicity.

Lyposomal cisplatin

Original Indication
1. Metastatic Testicular Tumors. In established combination therapy with other approved chemotherapeutic agents in patients with metastatic testicular tumors who have already received appropriate surgical and/or radiotherapeutic procedures. 2. Advanced Bladder Cancer. It is indicated as a single agent for patients with transitional cell bladder cancer which is no longer amenable to local treatments, such as surgery and/or radiotherapy.
New Indication
Treatment of osteogenic sarcoma metastatic to the lung.

L-cycloserine

Original Indication
Treatment of acute urinary tract infections caused by susceptible strains of gram positive and gramcnegative bacteria, especially Enterobacter spp. and Escherichia coli.
New Indication
Treatment of Gaucher's disease.

Liposomal doxorubicin hydrochloride

Original Indication
DOXIL (doxorubicin HCl liposome injection) is an anthracycline topoisomerase inhibitor indicated for: 1. Ovarian cancer - After failure of platinum-based chemotherapy. 2. AIDS-related Kaposi's Sarcoma -after failure of prior combination chemotherapy or intolerance to such therapy. 3. Multiple Myeloma - In combination with bortezomib in patients who have not previously received bortezomib and have received at least one prior therapy.
New Indication
Treatment of soft tissue sarcomas.

Liposomal topotecan hydrochloride

Original Indication
HYCAMTIN for Injection is a topoisomerase inhibitor indicated for:1. metastatic carcinoma of the ovary after failure of initial or subsequent chemotherapy. 2. small cell lung cancer sensitive disease after failure of first-line chemotherapy. 3. combination therapy with cisplatin for stage IV-B, recurrent, or persistent carcinoma of the cervix which is not amenable to curative treatment with surgery and/or radiation therapy.
New Indication
Treatment of gliomas.

Leflunomide

Original Indication
Arthiritis
New Indication
Myeloma

Load More