Repurposed Drug Database


Nabumetone

Original Indication
It is indicated for relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
New Indication
Treatment of pediatric juvenile rheumatoid arthritis.

Nevirapine

Original Indication
Use in combination with other antiretroviral agents for the treatment of HIV-1 infection.
New Indication
Prevention of HIV infection in pediatric patients under the age of 16 years.

Nitroprusside

Original Indication
1. The immediate reduction of blood pressure of patients in hypertensive crises. 2. Producing controlled hypotension in order to reduce bleeding during surgery. 3. The treatment of acute congestive heart failure.
New Indication
Treatment and prevention of cerebral vasospasm following subarachnoid hemorrhage.

Nilotinib

Original Indication
For the treatment of chronic phase and accelerated phase Philadelphia chromosome positive chronic myelogenous leukemia in adult patients resistant to or intolerant to prior therapy that included imatinib.
New Indication
Treatment of gastrointestinal stromal tumors.

Nitazoxanide

Original Indication
Treatment of diarrhea caused by Cryptosporidium parvum and Giardia lamblia.
New Indication
Treatment for intestinal amebiasis.

Nitisinone

Original Indication
Adjunctive therapy to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1.
New Indication
Treatment of alkaptonuria.

Nitric oxide

Original Indication
In conjunction with ventilatory support and other appropriate agents, in the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension, where it improves oxygenation and reduces the need for extracorporeal membrane oxygenation.
New Indication
Treatment of acute respiratory distress syndrome in adults.

N-acetylcysteine

Original Indication
Administered intravenously within 8 to 10 hours after ingestion of a potentially hepatotoxic quantity of acetaminophen, it is indicated to prevent or lessen hepatic injury .
New Indication
Treatment of acute liver failure.

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