Repurposed Drug Database


Sildenafil

Original Indication
Angina.
New Indication
Male erectile dysfunction.

Sibutramine

Original Indication
Depression.
New Indication
Obesity.

Sermorelin acetate

Original Indication
Treatment of idiopathic or organic growth hormone deficiency in children with growth failure.
New Indication
Adjunct to gonadotropin therapy in the induction of ovulation in women with anovulatory or oligo-ovulatory infertility who fail to ovulate in response to adequate treatment with clomiphene citrate alone and gonadotropin therapy alone.

Sodium phenylbutyrate

Original Indication
Adjunctive therapy in the chronic managment of patients with urea cycle disorders involving deficiencies of carbamylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase.
New Indication
Treatment for sickling disorders, which include S-S hemoglobinopathy, S-C hemoglobinopathy, and S-thalassemia hemoglobinopathy.

Sodium thiosulfate

Original Indication
Used in the treatment of cyanide poisoning. Sodium thiosulfate may be used in the management of extravasation of chlormethine and some other antineoplastics. It is also used to inactivate some antineoplastics before disposal. Sodium thiosulfate, given by intravenous infusion, has also been investigated for reducing the systemic toxicity of some antineoplastics. It has been reported to reduce the incidence of nephrotoxicity associated with intraperitoneal cisplatin.
New Indication
Prevention of platinum-induced ototoxicity in pediatric patients.

Somatropin

Original Indication
For long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion.
New Indication
Adjunct for the induction of ovulation in women with infertility due to hypogonadotropic hypogonadism or bilateral tubal occlusion or unexplained infertility, who are undergoing in vivo or in vitro fertilization procedures.

Succimer

Original Indication
Treatment of lead poisoning in children pediatric patients with blood lead levels above 45 g/dL.
New Indication
Prevention of cystine kidney stone formation in patients with homozygous cystinuria who are prone to stone development.

Sucralfate

Original Indication
1. Short-term treatment (up to 8 weeks) of active duodenal ulcer. 2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing ofacute ulcers.
New Indication
Treatment of oral mucositis and stomatitis following radiation therapy for head and neck cancer.

Sorafenib

Original Indication
Treatment of patients with advanced renal cell carcinoma.
New Indication
Treatment of stage IIB through stage IV melanoma.

Synthetic human secretin

Original Indication
For use in the diagnosis of gastrinoma associated with Zollinger-Ellison syndrome.
New Indication
For use in obtaining desquamated pancreatic cells for cytopathologic examination in pancreatic carcinoma.

Synthetic porcine secretin

Original Indication
For use in secretin stimulation testing for: Stimulation of pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangio-pancreatography (ERCP).
New Indication
For use in obtaining desquamated pancreatic cells for cytopathologic examination in pancreatic carcinoma.

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