Repurposed Drug Database


Topiramate

Original Indication
Epilepsy.
New Indication
Obesity.

Topiramate

Original Indication
Epilepsy.
New Indication
Irritable bowel syndrome.

Tofisopam

Original Indication
Anxiety-related conditions.
New Indication
Irritable bowel syndrome.

Tofisopam

Original Indication
Anxiety-related conditions.
New Indication
c AMP modulation by PDE4 inhibition.

Tadalafil

Original Indication
Inflammation and cardiovascular disease.
New Indication
Male erectile dysfunction.

Tenofovir disoproxil fumarate

Original Indication
It is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and adolescents. It is indicated for the treatment of chronic hepatitis B in adults.
New Indication
Treatment of pediatric HIV infection.

Testosterone propionate ointment 2%

Original Indication
Testosterone gel is an androgen indicated for replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone: Primary Hypogonadism (Congenital or Acquired) - testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter's syndrome, chemotherapy, or toxic damage from alcohol or heavy metals. Hypogonadotropic Hypogonadism (Congenital or Acquired) - idiopathic gonadotropin or luteinizing hormone-releasing hormone (LHRH) deficiency or pituitary-hypothalamic injury from tumors, trauma, or radiation.
New Indication
Treatment of vulvar dystrophies.

Tiotropium bromide

Original Indication
Tiotropium bromide inhalation powder is indicated for the long-term, once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It is also indicated to reduce exacerbations in COPD patients.
New Indication
To improve pulmonary function in conjunction with standard therapy in the management of patients with cystic fibrosis.

Toremifene

Original Indication
Treatment of metastatic breast cancer in postmenopausal women with estrogen positive or receptor unknown tumors.
New Indication
Treatment of desmoid tumors.

Tramadol hydrochloride

Original Indication
Management of moderate to moderately severe pain in adults.
New Indication
Management of postherpetic neuralgia.

Trastuzumab

Original Indication
As a single agent it is indicated for the treatment of patients with metastatic breast cancer whose tumors overexpress the HER2 protein and who have received one or more chemotherapy regimens for their metastatic disease. In combination with paclitaxel, it is indicated for treatment of patients with metastatic breast cancer whose tumors overexpress the HER2 protein and who have not received chemotherapy for their metastatic disease.
New Indication
Treatment of patients with pancreatic cancer that overexpress p185HER2.

Triptorelin pamoate

Original Indication
Palliative treatment of advanced prostate cancer.
New Indication
For use in the palliative treatment of advanced ovarian carcinoma of epithelial origin.

Tranexamic acid

Original Indication
Tranexamic acid Injection is indicated in patients with hemophilia for short-term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction.
New Indication
Treatment of hereditary angioneurotic edema.

Temozolomide

Original Indication
Treatment of adult patients with refractory anaplastic astrocytoma, i.e, patients at first relapse who have experienced disease progression on a drug regimen containing a nitrosourea and procarbazine.
New Indication
Treatment of advanced metastatic melanoma.

Tetrabenazine

Original Indication
Treatment of chorea associated with Huntington's disease.
New Indication
Treatment of moderate/severe tardive dyskinesia.

Thalidomide

Original Indication
Acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrences.
New Indication
Treatment of graft versus host disease in patients receiving bone marrow transplantation.

Tobramycin

Original Indication
TOBI is indicated for the management of cystic fibrosis patients with Pseudomonas aeruginosa.
New Indication
Treatment of bronchiectasis patients infected with Pseudomonas aeruginosa.

Tretinoin

Original Indication
Tretinoin capsule is indicated for induction of remission in patients with acute promyelocytic leukemia who are refractory to or unable to tolerate anthracycline based cytotoxic chemotherapeutic regimens.
New Indication
Treatment of squamous metaplasia of the ocular surface epithelia (conjunctiva and/or cornea) with mucous deficiency and keratinization.

Trimetrexate

Original Indication
Concurrent leucovorin administration as an alternative therapy for the treatment of moderate to severe Pneumocystis carinii pneumonia in immunocompromised patients including patients with the acquired immunodeficiency syndrome, who are intolerant of, or are refractory to, trimethoprim-sulfamethoxazole therapy or for whom trimethoprim-sulfamethoxazole is contraindicated.
New Indication
Treatment of metastatic carcinoma of the head and neck (i.e. buccal cavity, pharynx, and larynx).

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